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Updated: Aug 5, 2026

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
Published on: May 4, 2015
Hypoxic Preconditioning: An Underestimated Endogenous Protective Strategy?
Jinqiao Liu1, Changhong Ren2, Tariq Kermalli3
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Abstract:
Hypoxic Preconditioning (HPC) describes the phenomenon whereby brief, non-lethal hypoxic episodes enhance cellular resilience to subsequent severe hypoxia. Initially recognized in altitude studies, HPC has since been linked to broad protective effects, particularly in the protection of ischemia/hypoxia. This article highlights the biological rationale, potential mechanisms and applications, while addressing the challenges of clinical translation. As a form of endogenous adaptation, HPC offers a promising paradigm for preventive and therapeutic strategies across various diseases.
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