Related Experiment Video
Updated: Aug 5, 2026
07:20
Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Non-Pharmacological and Non-Optical Interventions for Myopia Prevention and Control in Children: A Systematic Review
Claudia Domínguez-Morras1, Miren Paniagua García2, Isabel Castro Garrido2
1Faculty of Science, Universidad Pública de Navarra, UPNA, 31008 Pamplona, Spain.
Children (Basel, Switzerland)
|July 28, 2026
Summary
Low-level red-light therapy (RLRL) effectively slows myopia progression in children by reducing axial elongation. Nutritional supplementation showed no significant impact on myopia control.
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Biomedical Engineering
Background:
- Myopia prevalence is projected to reach 50% globally by 2050, increasing risks of severe ocular pathologies.
- Non-pharmacological interventions are crucial for managing myopia progression in children and adolescents.
- Effective myopia control strategies are essential to mitigate long-term vision impairment.
Purpose of the Study:
- To assess the clinical efficacy of low-level red-light therapy (RLRL) for myopia control.
- To evaluate the impact of nutritional supplementation on myopia progression in pediatric populations.
- To synthesize evidence on non-pharmacological myopia prevention and management.
Main Methods:
- Systematic review and meta-analysis adhering to PRISMA guidelines.
- Inclusion of randomized clinical trials in pediatric populations (0-18 years).
- Primary outcomes: axial length (AL) and spherical equivalent (SE); assessed risk of bias and heterogeneity.
Main Results:
- RLRL significantly reduced axial elongation (MD: -0.26 mm) and refractive progression (MD: +0.60 D) in 18 studies (n=2438).
- High heterogeneity (I² > 97%) was observed for RLRL efficacy.
- Nutritional supplementation had a modest, non-significant effect on AL (MD: -0.22 mm).
Conclusions:
- RLRL demonstrates efficacy in slowing ocular elongation and myopia progression, with reassuring safety data when protocols are followed.
- Further research is needed due to high study heterogeneity, lack of standardized discontinuation protocols, and limited diverse population data.
- Current evidence does not support nutritional supplementation for clinically meaningful control of axial elongation in myopia.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:16Focusing of Light in the Eye
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...