Related Experiment Video
Updated: Aug 5, 2026
10:49
Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
Adhesive Hydrogel Loaded with Sulfonated Chitosan Promotes Oral Mucosal Defect Repair in Diabetic Rats
Xiaohui Zhang1,2, Gaopeng Wang2, Shuwen Ding3
1The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Bioengineering (Basel, Switzerland)
|July 28, 2026
Summary
A new adhesive hydrogel (ATDS) effectively repairs diabetic oral wounds by providing durable coverage and promoting healing. This biomaterial accelerates wound closure, enhances tissue regeneration, and reduces inflammation for better oral tissue repair.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Oral Biology
Background:
- Diabetic oral wounds heal poorly due to impaired biological processes.
- Effective wound repair requires biomaterials with strong adhesion, biocompatibility, and mechanical integrity.
- Existing treatments often lack durability in the oral environment.
Purpose of the Study:
- To develop an in situ photocurable adhesive hydrogel (ATDS) for diabetic oral mucosal wound repair.
- To evaluate the physical, mechanical, and biological properties of ATDS.
- To assess the efficacy of ATDS in promoting diabetic oral wound healing in an animal model.
Main Methods:
- Synthesis of a sulfonated chitosan-based hydrogel (ATDS).
- Characterization of ATDS's mechanical strength, adhesion, microstructure, and cytotoxicity.
- In vivo evaluation of ATDS in a diabetic rat model of oral mucosal defect.
- Assessment of wound closure, re-epithelialization, angiogenesis, and inflammatory markers.
Main Results:
- ATDS demonstrated excellent tensile strength (50 kPa), elongation at break (320%), and adhesive strength (0.605 MPa).
- ATDS provided durable wound coverage, unlike hyaluronic acid (HA) gel.
- In diabetic rats, ATDS significantly accelerated wound closure (near complete healing by day 6), promoted re-epithelialization by day 3, and increased epidermis thickness by ~50%.
- ATDS enhanced angiogenesis and reduced TNF-α and IL-1β expression.
Conclusions:
- ATDS is a promising biomaterial for diabetic oral wound healing.
- The hydrogel's efficacy stems from its barrier protection, pro-angiogenic, and anti-inflammatory properties.
- ATDS holds potential for oral tissue engineering and regenerative applications.
