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Updated: Aug 5, 2026
11:12
Determination of the Optimal Chromosomal Location(s) for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
Published on: September 11, 2017
Comparative Sequence-Structural Analysis of TdNV-Korea Entry Factors Identifies Candidate Regions Associated with
Yoon Ho Park1, Rana Kim1, Kun-Ho Song2
1Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.
International Journal of Molecular Sciences
|July 28, 2026
Summary
Viral host range in insects is crucial. Researchers identified specific viral entry factors, GP106 and GP126, in nudiviruses that may determine which insect species a virus can infect.
Area of Science:
- * Virology
- * Molecular Biology
- * Entomology
Background:
- * Emerging viral variants pose threats to insect production and wild populations.
- * Understanding viral host range is essential for managing these threats.
- * TdNV-Korea, an isolate from a non-Oryctes beetle, belongs to the Oryctes rhinoceros nudivirus (OrNV) lineage.
Purpose of the Study:
- * To identify molecular features influencing viral host range in OrNV isolates.
- * To compare sequence and structural properties of viral entry factors (GP106, GP126) and the major capsid protein (VP39).
Main Methods:
- * Sequence analysis of viral entry factors across OrNV-related isolates.
- * Structural modeling to predict protein properties.
- * Electrostatic surface analysis to identify potential host-interaction sites.
Main Results:
- * The major capsid protein VP39 showed high conservation across isolates.
- * Viral infectivity factors GP106 and GP126 exhibited greater sequence divergence.
- * GP106 maintained a conserved chitin-binding domain, with changes in its C-terminal region.
- * GP126 showed substitutions in a disordered interdomain segment, leading to an electrostatic shift on a potential host-interaction surface.
Conclusions:
- * Contrasting modes of sequence change were observed in GP106 and GP126.
- * The GP126 protein and the C-terminal region of GP106 are prioritized for future functional studies.
- * These findings provide a hypothesis for viral host-range determinants in nudiviruses.
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