Unlocking the Potential of Yellow Kepok Banana Peel Extract: An Innovative Solution for Treating Metabolic Disorders...

Diabetes mellitus is associated with chronic hyperglycemia, dyslipidemia, and systemic inflammation. Banana peel contains bioactive compounds with antioxidant and anti-inflammatory properties and may provide a natural therapeutic alternative. This study aimed to evaluate its potential effects on metabolic and inflammatory parameters in rabbits with HFFD-induced metabolic disturbances.

This preclinical experimental study involved 40 male New Zealand White rabbits (3-4 months; 1.5-2.0 kg) randomly assigned to four groups (n = 10): Healthy Control, HFFD control (HFFD-induced diabetes mellitus), and two treatment groups receiving either 0.3% sodium carboxymethyl cellulose (NaCMC) or banana peel extract (200 mg/kg body weight). Diabetes and hyperlipidemia were induced using a high fructose fat diet (HFFD) for two weeks, followed by a three-week treatment period. Blood samples were collected at baseline, post-induction, and posttreatment to measure glucose, triglycerides, and inflammatory markers (hsCRP and IL-10) using biochemical assays and ELISA. Histological evaluation was performed on tissue samples. Data were analysed using One-Way ANOVA or the Kruskal-Wallis test based on data distribution, with post hoc analysis and a significance level of p < 0.05.

Yellow banana peel extract (200 mg/kgBW) significantly reduced fasting blood glucose, triglycerides, and hsCRP levels while increasing IL-10 expression, indicating antidiabetic and anti- inflammatory effects in an HFFD-induced diabetic model.

The findings suggest that yellow kepok banana peel extract exhibits significant antihyperlipidemic and antidiabetic potential, which may be attributable to bioactive compounds previously reported in banana peel, which may improve lipid metabolism and glucose regulation.

Banana peel extracts showed potential as a supportive natural adjunct for improving glucose and lipid profiles in patients with diabetes mellitus. These findings suggest that extract- based natural products may improve metabolic control and reduce cardiovascular risk. Further studies are required to elucidate the underlying mechanisms and to confirm long-term safety and efficacy in clinical settings.