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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Selenium-Loaded Calcium Phosphate with Long-Term and Curative Dosage Drug Release for Post-Surgical Osteosarcoma
Yang Yan1, Yue Chen2,3, Danjie Meng4
1Zhejiang Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
International Journal of Molecular Sciences
|July 28, 2026
Summary
A novel selenium-loaded biomimetic calcium phosphate (Se@BioCaP) shows promise for treating osteosarcoma (OS) after surgery. This material offers sustained drug release, effectively killing cancer cells while supporting bone repair and fighting infection.
Area of Science:
- Biomaterials Science
- Oncology
- Nanotechnology
Background:
- Neoadjuvant chemotherapy for osteosarcoma (OS) can be suboptimal, leading to recurrence.
- Postoperative bone repair after OS surgery presents significant challenges.
Purpose of the Study:
- To develop a selenium-loaded biomimetic calcium phosphate (Se@BioCaP) for sustained postoperative OS treatment.
- To evaluate the therapeutic efficacy and biocompatibility of Se@BioCaP.
Main Methods:
- Sodium selenite was incorporated into biomimetic calcium phosphate (BioCaP) using a wet mineralization protocol.
- Release kinetics and cytotoxic effects on OS cells were analyzed under tumor-like conditions.
- Biocompatibility with osteoblasts (OBs) and antibacterial activity were assessed.
Main Results:
- Se@BioCaP demonstrated sustained release of cytotoxic selenium concentrations under acidic conditions.
- The material disrupted OS cell redox homeostasis, leading to reduced viability.
- Se@BioCaP maintained anticancer, pro-osteogenic, and antibacterial activities through day 42.
Conclusions:
- Se@BioCaP exhibits promising potential for managing osteosarcoma post-surgery.
- The material effectively targets cancer cells, aids bone regeneration, and prevents infection.
