ETDACVO: Structural-Fidelity-Aware Evolutionary Co-Optimization for Robust and Explainable Brain Tumor MRI...

Background/Objectives: Heterogeneous imaging protocols, a lack of labeled data, and domain shifts continue to make training deep learning models to analyze medical images a challenge. This study presents ETDACVO (Enhanced Tasmanian Devil Anti-Conservative Variable Optimization), a hybrid evolutionary optimization system designed to improve convergence stability and cross-domain robustness in brain tumor MRI classification. Methods: ETDACVO combines Tasmanian Devil Optimization (TDO), Anti-Conservative Variable Optimization (ACVO), and Exponentially Weighted Moving Average (EWMA) smoothing to stabilize evolutionary parameter updates. Unlike existing approaches that optimize augmentation policies or optimizer dynamics separately, ETDACVO simultaneously evolves both components within a single evolutionary loop. The framework was evaluated on four MRI datasets (Nickparvar, Mendeley, BRISC, and Figshare), comprising 28,151 images. In addition, a convergence-aware explainability mechanism, CA-EA-GradCAM, was developed by integrating gradient saliency, transformer attention, and evolutionary convergence confidence to generate confidence-sensitive tumor localization maps. Results: Experimental results demonstrated that ETDACVO achieved a 2.3-2.5% improvement in classification accuracy and converged 19-22 epochs faster than baseline optimizers. The statistical significance of these improvements was confirmed using paired statistical tests (p < 1 × 10^-5). Cross-dataset transfer experiments further showed strong domain-shift resilience, with performance retention reaching 92.8%. The proposed CA-EA-GradCAM mechanism provided interpretable and confidence-aware tumor localization maps. Conclusions: ETDACVO provides a robust and computationally efficient optimization framework for deep-learning-based medical image analysis. By jointly optimizing augmentation strategies and optimizer dynamics, the framework enhances convergence stability, cross-domain robustness, and interpretability, making it a promising approach for reliable brain tumor MRI classification under heterogeneous imaging conditions.