Related Experiment Video
Updated: Aug 5, 2026
11:12
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Breast Cancer: Epidemiology, Molecular Classification, Diagnostics and Evolving Treatment Paradigms
Jeremiah Oshiomame Unuofin1, Adedoyin Omobolanle Adefisan-Adeoye2,3, Oluwatomiwa Kehinde Paimo4
1Department of Life and Consumer Sciences, University of South Africa, Johannesburg 1709, South Africa.
Molecules (Basel, Switzerland)
|July 28, 2026
Summary
This review covers breast cancer genetics, diagnostics, and treatments. Emerging strategies like nanotechnology and gene editing aim to improve efficacy and overcome resistance in breast cancer care.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Breast cancer is a leading cause of cancer mortality in women globally.
- Outcomes are increasingly tied to molecular subtypes and genetic profiles.
- Genetic mutations significantly influence breast cancer development, progression, and metastasis.
Purpose of the Study:
- To review key genetic factors in breast cancer.
- To highlight current and emerging diagnostic and therapeutic strategies.
- To discuss future clinical management approaches based on genetic insights.
Main Methods:
- Review of current literature on breast cancer genetics, diagnostics, and therapeutics.
- Analysis of diagnostic techniques including imaging and biopsies.
- Examination of systemic therapies, targeted agents, and novel approaches.
Main Results:
- Key genes like BRCA1/2, PIK3CA, and TP53 are crucial in breast cancer.
- Personalized treatments based on molecular profiling improve outcomes.
- Advanced therapies include immunotherapy, PARP inhibitors, and antibody-drug conjugates.
- Treatment resistance and recurrence, especially in triple-negative breast cancer, remain challenges.
Conclusions:
- Advances in understanding breast cancer genetics enable personalized medicine.
- Emerging strategies like nanotechnology, gene editing (CRISPR-Cas9), and vaccines offer new hope.
- Future research focuses on enhancing efficacy, reducing toxicity, and overcoming resistance.
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