Subject-Specific Finite Element Analysis of the Human Femur Using Radiation-Free Three-Dimensional Zero-Echo-Time...

Finite element (FE) modeling is widely used in biomechanical research, enabling computational investigations of anatomical structures. To develop accurate FE models, high-resolution medical imaging such as computed tomography (CT) is essential. However, CT exposes patients to ionizing radiation. Recently, radiation-free three-dimensional zero-echo-time magnetic resonance imaging (3D ZTE MRI) has shown promising results for bone visualization. Therefore, this feasibility study investigated whether 3D ZTE MRI is reliable for creating subject-specific FE models. Human femora from four female subjects were imaged using 3D ZTE MRI. Static FE analyses of the femora were performed in Abaqus/CAE, assuming a biphasic homogenous linear-elastic material. A sensitivity analysis was conducted to evaluate varying bone material properties. After loading with 2000 N, the mean displacement of the femoral head amounted to -1.30 ± 0.26 mm (vertical) and -9.03 ± 2.21 mm (horizontal), while the femoral neck exhibited compressive (inferior: -1366.03 ± 182.70 µm/m) and tensile (superior: 1038.69 ± 135.82 µm/m) strains. Overall, the results demonstrate displacement and strain predictions similar to previous experimental and computational studies based on CT data. Therefore, despite several simplifications, these findings confirm the feasibility of radiation-free 3D ZTE MRI for subject-specific FE modeling, enabling future simultaneous assessment of bone morphology and surrounding soft tissues.