Related Experiment Video
Updated: Aug 12, 2026
04:45
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Published on: May 10, 2021
Risk Factors for a Systemic Inflammatory Response After Major Oral Cancer Surgery with Microvascular Free Flap
Noah-Benedikt Kukulenz1, Tobias Schuerholz2,3, Michael Dau1
1Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University Medical Centre Rostock, Rostock, Germany.
Journal of Inflammation Research
|August 11, 2026
Summary
This study identified key risk factors for systemic inflammatory response syndrome (SIRS) after oral cancer surgery with microvascular reconstruction. Preoperative leukocyte count and intraoperative blood loss are significant predictors, while dexamethasone may be protective and ibuprofen increases risk.
Area of Science:
- Oncology
- Surgical Oncology
- Inflammation Research
Background:
- Microvascular free flap reconstruction is standard for oral cancer defects.
- Systemic inflammatory response syndrome (SIRS) impacts surgical outcomes but its risk factors are unclear.
- Understanding SIRS determinants is crucial for improving patient recovery after oral cancer surgery.
Purpose of the Study:
- To identify risk factors for SIRS in patients undergoing oral cancer surgery with microvascular reconstruction.
- To investigate the association between identified risk factors and postoperative complications.
- To provide insights for optimizing patient management and reducing SIRS incidence.
Main Methods:
- Retrospective analysis of 123 patients undergoing oral cancer surgery and microvascular reconstruction.
- Data collected from institutional hospital information systems.
- Statistical analysis including univariate and multivariate logistic regression to identify predictors of SIRS.
Main Results:
- Systemic inflammatory response syndrome (SIRS) occurred in 41.5% of patients.
- Independent predictors for SIRS included preoperative leukocyte count, postoperative transfusions, and intraoperative blood loss.
- Postoperative dexamethasone showed a potential protective association, while ibuprofen administration was associated with increased risk.
Conclusions:
- Clinicians must recognize risk factors for SIRS post-oral cancer surgery.
- Preoperative leukocyte count and intraoperative blood loss are critical independent predictors.
- Dexamethasone and ibuprofen associations require further investigation but suggest potential therapeutic implications.