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Harnessing Natural Bioactive Compounds for Ocular Health: A Comprehensive Review
Hemant Ahirwar1, Harshita Singhai1, Sunny Rathee1
1Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, 470003, India.
Current Pharmaceutical Design
|July 28, 2026
Summary
Natural compounds show promise for eye health, combating disorders like macular degeneration. Nanotechnology enhances their delivery, improving bioavailability and therapeutic effects for better ocular care.
Area of Science:
- Ophthalmology and Pharmacology
- Natural Product Chemistry
- Nanotechnology in Medicine
Background:
- Ocular disorders pose a significant global health challenge.
- Natural compounds like carotenoids and flavonoids offer antioxidant and anti-inflammatory benefits for eye tissues.
- Challenges in clinical use include poor solubility, stability, and bioavailability of these natural compounds.
Purpose of the Study:
- To review the evidence on natural compounds for ocular health.
- To evaluate their mechanisms, safety, and potential.
- To explore nanotechnology-based delivery systems for enhanced efficacy.
Main Methods:
- Comprehensive review of in vitro, in vivo, and clinical studies.
- Analysis of natural compounds (carotenoids, flavonoids, herbal extracts).
- Evaluation of nanotechnology platforms (nanoparticles, nanoemulsions, liposomes).
Main Results:
- Natural compounds exhibit antioxidant, anti-inflammatory, and neuroprotective effects on ocular tissues.
- Nanotechnology significantly improves solubility, stability, and ocular bioavailability.
- Personalized nanoformulations combined with traditional medicine offer holistic eye care.
Conclusions:
- Natural compounds, enhanced by nanotechnology, present a promising strategy for managing ocular disorders.
- Integration of traditional systems with modern ophthalmic approaches is key for patient-centered eye care.
- Addressing challenges in standardization, regulation, and manufacturing is crucial for future development.
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