Biocatalysis: an enabling technology for pharmaceutical chemistry

Area of Science:

• Green Chemistry
• Biocatalysis
• Pharmaceutical Synthesis

Background:

• Growing demand for sustainable and eco-friendly pharmaceutical production processes.
• Need for biocatalysts with enhanced activity, specificity, thermal stability, and solvent tolerance.
• Biocatalysis is increasingly adopted in pharmaceutical chemistry.

Purpose of the Study:

• To review advanced screening and enzyme engineering techniques for biocatalyst development.
• To provide an overview of biocatalytic methods in pharmaceutical synthesis.
• To highlight the application of biocatalysis in producing various bioactive compounds.

Main Methods:

• Examination of advanced screening techniques for enzyme discovery.
• Description of enzyme engineering procedures for biocatalyst optimization.
• Review of biocatalytic applications in pharmaceutical synthesis, including preparative-scale production.

Main Results:

• Identification and development of enzymes for synthetic applications.
• Successful application of biocatalysis in producing compounds with antiviral, anticancer, neuroprotective, cardiovascular-protective, antibacterial, and antiparasitic activities.
• Demonstration of biocatalysis in both early and late stages of pharmaceutical research and development.

Conclusions:

• Biocatalysis is a key strategy for sustainable pharmaceutical manufacturing.
• Advanced screening and engineering are crucial for developing high-performance biocatalysts.
• Biocatalysis enables efficient synthesis of a wide range of therapeutic agents.