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L-Dopa-asparagine-derived carbon dots as a targeted theranostic agent for melanoma
Debolina Basu1, Afreen Zaman1, Prasanta Kumar Das1
1School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India. bcpkd@iacs.res.in.
Chemical Communications (Cambridge, England)
|July 28, 2026
Abstract:
L-Dopa-asparagine-derived carbon dots (DACDs) were developed for the preferential diagnosis and targeted therapy of melanoma. DACD exhibited ∼2.8-fold and clioquinol (FIH-1 inhibitor)-loaded DACD exhibited ∼3.3-fold greater cytotoxicity towards B16F10 than NIH3T3 cells via enhanced hypoxia and ROS-induced apoptosis during the conversion of L-dopa to melanin.
