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Focused Review on pH- and Temperature-Responsive Pectin-Based Hydrogels for Drug Delivery and Controlled Release
Thanapon Deekaikam1, Ain Us Saba1, Jun Chen2
1Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
Pectin-based hydrogels can be modified to create smart drug delivery systems. These stimuli-responsive materials offer enhanced site-specific drug release for biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Stimuli-responsive hydrogels offer controlled drug release kinetics.
- Natural macromolecules like pectin are promising for biomedical hydrogels due to biocompatibility and biodegradability.
- Pectin's chemical structure allows modifications for enhanced environmental trigger responsiveness.
Purpose of the Study:
- To review advancements in modifying pectin for stimuli-responsive hydrogels.
- To explore pectin's potential in site-specific, stimuli-responsive drug delivery.
- To discuss mechanisms of pH and temperature responsiveness in pectin hydrogels.
Main Methods:
- Review of recent literature on pectin modifications.
- Analysis of chemical strategies to enhance pectin responsiveness.
- Discussion of underlying mechanisms for stimuli-responsive behavior.
Main Results:
- Pectin modifications can significantly improve pH and temperature responsiveness.
- Chemically modified pectin hydrogels show potential for controlled drug release.
- Understanding mechanisms is key to optimizing pectin-based smart hydrogels.
Conclusions:
- Pectin is a versatile natural polymer for developing stimuli-responsive hydrogels.
- Modified pectin hydrogels hold significant promise for advanced drug delivery systems.
- Further research into pectin-based hydrogels can unlock new therapeutic possibilities.
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