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Updated: Aug 5, 2026
08:12
Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry
Published on: October 4, 2024
Exercise-induced mitochondrial remodeling in energy-demanding organs during aging
Zhuoyang Zhou1,2, Jianhong Gao3,2, Minghui Wang4
1College of Physical Education and Health, Anhui University of Chinese Medicine, Hefei 230012, China.
Iscience
|July 28, 2026
Summary
Regular physical exercise preserves mitochondrial integrity, combating age-associated organ dysfunction. This review explores how exercise restores mitochondrial homeostasis to mitigate aging and chronic diseases across multiple organs.
Area of Science:
- Gerontology and Exercise Physiology
- Mitochondrial Biology
- Molecular Mechanisms of Aging
Background:
- Aging leads to organ dysfunction, impaired mitochondrial function, and increased chronic disease risk.
- Mitochondrial dysfunction contributes to oxidative stress, inflammation, and cellular senescence.
- Skeletal muscle, brain, heart, kidneys, and liver are particularly vulnerable to age-related mitochondrial decline.
Purpose of the Study:
- To review the effects of exercise on mitochondrial regulation across various organs.
- To elucidate molecular mechanisms by which exercise confers anti-aging benefits.
- To provide a cross-organ analysis of exercise-induced mitochondrial adaptations.
Main Methods:
- Comprehensive literature review of studies on exercise and mitochondrial function in aging.
- Analysis of molecular pathways involved in exercise-mediated mitochondrial protection.
- Cross-organ comparison of exercise responses in mitochondrial homeostasis.
Main Results:
- Physical exercise preserves mitochondrial integrity and function in multiple organs.
- Exercise mitigates age-related increases in reactive oxygen species and inflammation.
- Exercise promotes mitochondrial biogenesis and improves energy metabolism.
Conclusions:
- Regular physical exercise is a key intervention for attenuating aging and preventing organ dysfunction.
- Exercise restores mitochondrial homeostasis, offering a theoretical basis for anti-aging strategies.
- Lifestyle modifications, including exercise, can enhance healthspan and reduce mortality in older adults.
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