Design, Synthesis, and Fungicidal and Insecticidal Activities of Methoxyacrylate Derivatives via Linker Modification

To discover novel and highly effective pesticides with diverse structures, 16 new methoxyacrylate compounds were designed and synthesized based on linker modification. All target compounds were characterized by ¹H NMR, ¹³C NMR, and HRMS. Preliminary bioassay results indicated that some target compounds exhibited good fungicidal activity against Phakopsora pachyrhizi, Sphaerotheca fuliginea, and Pyricularia oryzae, as well as potent insecticidal activity against Plutella xylostella, Mythimna separata, and Aphis craccivora. Notably, compound 10b showed 100% control efficacy against Phakopsora pachyrhizi at 0.4 mg/L, 100% control efficacy against Sphaerotheca fuliginea at 25 mg/L, and 88.89% control efficacy against Pyricularia oryzae at 100 mg/L. Meanwhile, compound 10b exhibited 69.05% mortality against Aphis craccivora at 4 mg/L and 100% mortality against Mythimna separata at 10 mg/L, demonstrating broad-spectrum activity. These findings may provide valuable insights for the development of novel and highly effective methoxyacrylate derivatives.