Design, Synthesis, and Fungicidal and Insecticidal Activities of Methoxyacrylate Derivatives via Linker Modification

Area of Science:

• Agricultural Chemistry
• Organic Synthesis
• Pest Management

Background:

• Development of novel pesticides is crucial for sustainable agriculture.
• Methoxyacrylates represent a class of compounds with potential pesticidal properties.
• Existing pesticides face challenges like resistance and environmental impact.

Purpose of the Study:

• To design and synthesize novel methoxyacrylate derivatives.
• To evaluate the fungicidal and insecticidal activities of the synthesized compounds.
• To identify lead compounds for future pesticide development.

Main Methods:

• Synthesis of 16 new methoxyacrylate compounds via linker modification.
• Characterization using nuclear magnetic resonance (1H NMR, 13C NMR) and high-resolution mass spectrometry (HRMS).
• Preliminary bioassays to assess fungicidal activity against Phakopsora pachyrhizi, Sphaerotheca fuliginea, Pyricularia oryzae, and insecticidal activity against Plutella xylostella, Mythimna separata, Aphis craccivora.

Main Results:

• Compound 10b exhibited excellent fungicidal efficacy: 100% against P. pachyrhizi at 0.4 mg/L and S. fuliginea at 25 mg/L, and 88.89% against P. oryzae at 100 mg/L.
• Compound 10b demonstrated potent insecticidal activity: 69.05% mortality against A. craccivora at 4 mg/L and 100% mortality against M. separata at 10 mg/L.
• Several synthesized compounds showed promising fungicidal and insecticidal activities, indicating broad-spectrum potential.

Conclusions:

• The synthesized methoxyacrylate derivatives hold promise as effective pesticides.
• Compound 10b is a potential lead candidate for developing new fungicides and insecticides.
• Further research into these methoxyacrylate derivatives could lead to novel pest control solutions.