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Updated: Aug 5, 2026
06:24
Minimal Erythema Dose (MED) Testing
Published on: May 28, 2013
Erythema Elevatum Diutinum
Seda Sahin1, Campbell L Stewart2
1University of Connecticut School of Medicine, Farmington, CT, USA.
Clinics in Dermatology
|July 28, 2026
Summary
Erythema elevatum diutinum (EED) is a rare vasculitis linked to systemic diseases. Early diagnosis and treatment, often with dapsone, are crucial for managing EED and its underlying conditions.
Area of Science:
- Dermatology
- Immunology
- Pathology
Background:
- Erythema elevatum diutinum (EED) is a rare, chronic vasculitis.
- It often presents with symmetrical papules, plaques, or nodules on extensor surfaces.
- EED can be associated with systemic conditions like hematologic malignancies, autoimmune disorders, and infections.
Purpose of the Study:
- To summarize the clinical presentation, histology, and management of EED.
- To highlight the importance of recognizing EED as a potential indicator of underlying systemic disease.
- To discuss current treatment strategies and their impact on disease course.
Main Methods:
- Review of clinical and histological features of EED.
- Analysis of associations with systemic diseases.
- Summary of treatment approaches, including dapsone, corticosteroids, and immunosuppressants.
Main Results:
- EED is characterized by leukocytoclastic vasculitis and neutrophilic infiltration.
- Lesions typically appear on elbows, knees, and hands.
- Dapsone is the first-line treatment, with other agents used for resistant cases.
Conclusions:
- EED requires early diagnosis and management due to its association with serious systemic diseases.
- While no cure exists, treatment can influence the disease course.
- Addressing underlying conditions is key to improving outcomes for EED patients.
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