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Updated: Aug 5, 2026
08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Acrokeratosis paraneoplastica (Bazex syndrome)
Humza Zaidi1, Campbell L Stewart2
1University of Connecticut School of Medicine, Farmington, CT, USA.
Clinics in Dermatology
|July 29, 2026
Summary
Acrokeratosis paraneoplastica of Bazex (APB) is a skin condition that signals an underlying cancer, often squamous cell carcinoma. Early recognition of its distinct skin signs aids in prompt cancer diagnosis and treatment.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Acrokeratosis paraneoplastica of Bazex (APB) is a rare paraneoplastic dermatosis.
- It frequently indicates an underlying squamous cell carcinoma, particularly of the upper aerodigestive tract.
Purpose of the Study:
- To summarize the clinical, histological, and immunofluorescence findings of APB.
- To emphasize the importance of recognizing APB for early cancer detection.
Main Methods:
- Review of clinical presentations and histopathological findings in APB.
- Discussion of proposed pathomechanisms and diagnostic markers.
Main Results:
- APB presents with psoriasiform, violaceous, scaly plaques on acral areas, ears, and nose, often involving nails.
- Histology shows spongiosis, interface dermatitis, and lichenoid inflammation.
- Variable immunoglobulin and complement deposits may be seen on direct immunofluorescence.
Conclusions:
- APB is a crucial indicator of occult malignancy, often preceding diagnosis by months.
- Management primarily involves treating the underlying cancer, leading to resolution of skin lesions.
- Symptomatic treatment can provide relief but does not address the root cause.
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