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Updated: May 14, 2025

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
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Optical Coherence Tomography in Retinal Detachment: Prognostic Biomarkers, Surgical Planning, and Postoperative
Humza Zaidi1, Jayanth Sridhar2
1School of Medicine, University of Connecticut, Farmington, CT 06032, USA.
Diagnostics (Basel, Switzerland)
|April 12, 2025
Summary
Optical coherence tomography (OCT) advances retinal detachment (RD) diagnosis and surgical planning. OCT imaging provides key biomarkers for predicting outcomes and guiding treatment in this ocular emergency.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Retinal detachment (RD) is a critical condition requiring prompt medical attention.
- Accurate diagnosis and surgical planning are essential for successful RD treatment.
Purpose of the Study:
- To review the evolving role of optical coherence tomography (OCT) in managing retinal detachment.
- To synthesize literature on OCT biomarkers and advanced imaging for diagnosis, prognosis, and surgical planning.
Main Methods:
- Literature review of studies using spectral-domain OCT, swept-source OCT, OCT angiography, adaptive optics OCT, and en face OCT.
- Assessment of OCT findings including photoreceptor integrity, RD height, intraretinal cysts, outer retinal changes, and macular involvement.
Main Results:
- OCT provides detailed preoperative insights into RD pathology.
- Advanced OCT modalities can assess structural integrity and macular status, informing surgical decisions.
Conclusions:
- OCT integration into clinical practice can improve surgical timing, technique selection, and postoperative monitoring for RD.
- Further research is needed to standardize OCT protocols and validate prognostic biomarkers for optimal outcomes.

