tsRNA's Biological Function and its Potential Application in Disease Diagnosis and Prognosis

Under physiological conditions, tsRNAs regulate mRNA transcription, reverse transcription, and protein translation to mediate cell apoptosis, cell cycle, and epigenetic regulation. Pathogenic tsRNAs are disease-specific or disease-related tsRNAs that are highly express in various diseases and may serve as diagnostic or potential diagnostic biomarkers. Specifically expressed tsRNAs in tumors were screened and obtained from the tumors. Although the mechanisms by which these oncogenic tsRNAs contribute to tumor development remain unclear, they have been shown to be applicable to tumor diagnosis and therapeutic prognosis. This article briefly summarizes pathogenic tsRNAs involved in various diseases and their biological functions. Oncogenic tsRNAs in tumors and their clinical applications have been elaborated upon. The molecular mechanisms of pathological tsRNAs in both general diseases and tumors need to be further investigated in future.