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Adult Undifferentiated Embryonal Sarcoma of the Liver with Spontaneous Tumor Rupture and Comprehensive Molecular
Deepika Beereddy1, Durga Naga Malleswara Rao Jonnalagadda1, Pratap Tetali2
1Department of Internal Medicine, Reading Hospital-Tower Health, West Reading, PA, USA.
Case Reports in Oncology
|July 29, 2026
Summary
Undifferentiated embryonal sarcoma of the liver (UESL) is rare in adults. This case highlights diagnostic challenges, prognostic factors like tumor rupture, and molecular profiling for potential future treatments.
Area of Science:
- Hepatobiliary Malignancies
- Pediatric Oncology in Adults
- Surgical Oncology
Background:
- Undifferentiated embryonal sarcoma of the liver (UESL) is an aggressive neoplasm predominantly affecting children.
- Adult UESL is exceptionally rare and associated with a poor prognosis (30-48% 5-year survival) and lacks standardized treatment.