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Stage-Adaptive Janus Microneedle System for Redox-Immune Regulation and Mitochondrial Protection in Infected Diabetic
Mengting Yin1,2, Yu Zhang3, Xinyu Qu2
1Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, People's Republic of China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 29, 2026
Summary
A novel microneedle patch delivers staged therapy for infected diabetic wounds, combining antibacterial action with redox-immune regulation and promoting tissue repair. This approach accelerates healing by targeting key pathological factors.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Diabetic wounds involve complex cycles of infection, oxidative stress, and inflammation, hindering tissue repair.
- Existing treatments often fail to address these interconnected pathological factors comprehensively.
Purpose of the Study:
- To engineer a stage-adaptive Janus microneedle patch (MN-FeSAC-PPE) for sequential therapeutic interventions in infected diabetic wounds.
- To investigate the patch's ability to transition from antibacterial action to redox-immune microenvironment remodeling and tissue regeneration.
Main Methods:
- Integration of iron single-atom nanozymes (Fe-SACs) for near-infrared light-activated antibacterial activity.
- Loading of propolis extract (PPE) into microneedle tips for antioxidant and anti-inflammatory effects.
- In vitro assays (fibroblast protection, inflammatory factor analysis) and in vivo studies on infected diabetic wound models.
Main Results:
- MN-FeSAC-PPE demonstrated potent antibacterial activity and enhanced antioxidant defense in vitro.
- The patch suppressed pro-inflammatory factors and protected fibroblasts from oxidative damage.
- In vivo, the microneedle patch significantly accelerated wound closure, improved angiogenesis, and promoted collagen remodeling in S. aureus-infected diabetic wounds.
Conclusions:
- The stage-adaptive MN-FeSAC-PPE platform effectively manages the complex pathology of infected diabetic wounds.
- This microneedle system offers a promising strategy for regulating the redox-immune microenvironment and promoting diabetic wound healing.
