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Updated: Jan 15, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Thiofunctionalization of Silyl Enol Ether: An Efficient Approach for the Synthesis of β-Keto Sulfides
Xinyao Zhao1, Hexia Ye1, Yajie Fu1
1State Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.
Abstract:
β-Keto sulfides are a class of compounds containing both carbonyl (C=O) and thioether (C-S-C) functionalities, exhibiting significant potential in the field of medicinal chemistry. This study employs the silyl enol ether as the substrate, enabling the formation of C-S bonds under catalyst- and additive-free conditions, thereby facilitating the efficient synthesis of β-keto sulfides. The reaction proceeds rapidly and efficiently, exhibiting a broad substrate scope, and a total of 31 target compounds were synthesized with up to 95% yields.
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