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The neuroscience of childhood brain cancers
1Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Abstract:
Nervous system activity drives both normal neurodevelopment and childhood brain cancers through paracrine and synaptic signaling. In childhood gliomas, cancer cells integrate structurally and electrically into neural networks, and neuron-cancer interactions are strongly growth-promoting. Understanding the neuroscience mechanisms regulating childhood brain cancers opens a previously unexplored avenue for much-needed therapeutic interventions.
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