Related Experiment Video
Updated: Aug 5, 2026
Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions
Published on: April 28, 2026
Marginal Impact of Intralesional Regimens in Oral Submucous Fibrosis: A Tertiary-Centre Retrospective Study
Chandrashekhar Chattopadhyay1, Vikas Deo1, Charu Chouhan1
1Department of Dental Surgery, Dr S. N. Medical College & Hospital, Jodhpur, Rajasthan India.
Background:
Oral submucous fibrosis (OSMF) is a chronic, progressive, potentiallymalignant disorder. Intralesional triamcinolone acetonide (TA) + hyaluronidase (HA)remains widely used, yet its functional effectiveness in real-world settings is uncertain.
Methods:
A retrospective cohort (n = 54; Stage II-III) received six biweekly TA 20 mg +HA 750 IU injections plus adjuncts continued for six months. Outcomes: change inmaximum inter-incisal opening (MIO), pain (VAS), quality of life (OHIP-14), andhaemoglobin. Linear regression tested predictors (baseline MIO, stage, anaemia,compliance).
Results:
Mean MIO 22.4-24.6 mm (Δ 2.2 mm; p = 0.08; d = 0.49); 11% achieved ≥ 5mm gain. VAS decreased by 1 point (p = 0.04); OHIP-14 unchanged (p = 0.13).Regression R² = 0.07 (adjusted R² = 0.03; F(4,49) = 0.92, p = 0.46). No adverse events;compliance 65%.
Conclusion:
Intralesional TA + HA yielded limited functional improvement and modestsymptom relief. Multimodal, preventive, and regenerative approaches requireprospective validation.
