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Breast and Ovarian Cancer Among Individuals Undergoing BRCA1 and BRCA2 Testing

Fahima Dossa1, Kelly Metcalfe2,3, Zharmaine Ante4

  • 1Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California.

JAMA Network Open
|July 30, 2026
PubMed
Summary

Lifetime cancer risks for women undergoing BRCA testing vary significantly by genetic result and family history. Elevated breast cancer risks were observed even with variants of uncertain significance or negative results, necessitating personalized risk management.

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