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Screening for diabetic retinopathy with artificial intelligence in a primary care setting: a comparative cost
Livio Di Matteo1, Noelle Whitestone2, Vishaal Bhambhwani3,4
1Lakehead University, Thunder Bay, Ontario, Canada.
BMJ Open Ophthalmology
|July 30, 2026
Summary
Autonomous artificial intelligence (AI) screening for diabetic retinopathy (DR) is more cost-effective than physician-based screening. This AI approach significantly lowers the cost per diagnosed DR case in primary care settings.
Area of Science:
- Ophthalmology
- Artificial Intelligence
- Health Economics
Background:
- Diabetic retinopathy (DR) is a leading cause of vision loss in diabetic patients.
- Early detection and treatment of DR are crucial to prevent blindness.
- Current screening methods often rely on physician referrals, which can be resource-intensive.
Purpose of the Study:
- To conduct a comparative cost analysis of autonomous artificial intelligence (AI)-based screening for diabetic retinopathy (DR).
- To compare the costs of AI-based DR screening with the traditional physician-based referral system in a primary care setting.
Main Methods:
- A cost analysis was performed comparing autonomous AI-based DR screening with physician-based screening.
- Data sources included published costs, provincial billing codes, and clinical study data.
- Costs analyzed encompassed direct operational expenses, physician fees, and indirect patient time costs.
Main Results:
- Autonomous AI screening successfully screened 202 participants, with a 93.6% completion rate.
- The AI-based approach cost $13,647.84 per 100 patients, while physician-based screening cost $28,238.09 per 100 patients.
- The cost per diagnosed DR case was 52% lower with AI ($620.36) compared to physician-based screening ($1283.55).
Conclusions:
- Autonomous AI-based DR screening demonstrates significant cost advantages over traditional physician-based methods.
- The lower cost per diagnosed case highlights the potential benefits of implementing AI for DR screening in primary care.
- AI-based screening offers a more economically viable solution for managing diabetic retinopathy.