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Characterization of a New HIV-1 Circulating Recombinant Form CRF142_BC - Yunnan, China, 2015 and 2021
Min Chen1, Huichao Chen2, Shouxiong Lei3
1Yunnan Provincial Key Laboratory of Public Health and Biosafety & Health Laboratory Center, Yunnan Center for Disease Control and Prevention, Kunming City, Yunnan Province, China.
What Is Already Known About This Topic?:
Recombinant strains dominate the human immunodeficiency virus 1 (HIV-1) epidemic in China. Yunnan Province was the first region in China to report HIV-1 infections in batches. The long-term HIV-1 epidemic led to the generation of various recombinant forms. Among the 47 circulating recombinant forms (CRFs) reported in China, more than 20 were first identified in Yunnan Province.
What Is Added By This Report?:
This study reported a previously unrecognized HIV-1 CRF (CRF142_BC) characterized by the insertion of four short subtype B fragments into the subtype C backbone. CRF142_BC was estimated to have emerged in the mid-1990s, close to the time of the emergence of most known CRF_BCs in China.
What Are The Implications For Public Health Practice?:
The discovery of new CRFs will provide a basis for HIV-1 molecular tracing and intervention research. In addition, HIV-1 recombination can alter viral biological properties. The study of HIV-1 gene variants needs to be intensified.
