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Aptamer-based DNA nanoswitches for multiplexed protein detection
Sravya Kovvali1, Camryn A Beckles1,2, Arun Richard Chandrasekaran1,3
1The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222 USA. khalvorsen@albany.edu.
Chemical Communications (Cambridge, England)
|July 31, 2026
Summary
Researchers developed a simple, sensitive DNA nanoswitch platform for detecting key blood proteins. This technology enables dual detection of thrombin and vascular endothelial growth factor (VEGF) for healthcare applications.
Area of Science:
- Biotechnology
- Molecular Diagnostics
- Nanotechnology
Background:
- Protein detection is crucial for healthcare and research.
- Existing methods can be complex or lack sensitivity.
- Need for simple, modular platforms for protein analysis.
Purpose of the Study:
- To develop a novel platform for simple, sensitive, and specific protein detection.
- To combine aptamer-based recognition with DNA nanoswitches.
- To demonstrate dual detection of clinically relevant proteins.
Main Methods:
- Utilized aptamer-based recognition for target protein binding.
- Employed conformationally-responsive DNA nanoswitches.
- Integrated aptamers and nanoswitches for a modular detection system.
Main Results:
- Successfully demonstrated simple and sensitive protein detection.
- Achieved specific detection of target proteins.
- Validated the platform through dual detection of thrombin and vascular endothelial growth factor (VEGF).
Conclusions:
- The developed DNA nanoswitch platform offers a promising approach for protein detection.
- This technology has potential applications in diagnostics and biomedical research.
- The modular nature allows for adaptation to detect various biologically relevant proteins.
