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Updated: Aug 5, 2026
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Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
Published on: September 2, 2015
Self-powered electronics-free Wearable Disposable Electrotherapy (WDE) platform for accelerated wound healing
Mojtaba Belali Koochesfahani1, Kyle Donnery1, Abhiramalakshmi Senthil Kumar1
1The City College of New York, Dept of Biomedical Engineering.
Biorxiv : the Preprint Server for Biology
|August 1, 2026
Summary
A new wearable disposable electrotherapy (WDE) patch accelerates wound healing by delivering electrical stimulation like a bandage. This novel device significantly enhances tissue repair and remodeling, offering a practical solution for faster wound closure.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Wound Healing Research
Background:
- Electrical stimulation accelerates wound repair by modulating bioelectric signals.
- Clinical translation is limited by cumbersome devices and workflow disruption.
- A novel wearable, disposable electrotherapy (WDE) device offers a practical solution.
Purpose of the Study:
- To evaluate the efficacy of WDE in a rat wound model.
- To compare WDE performance against sham treatment and conventional electrical stimulation.
- To establish a biophysical framework for electrical stimulation in wound healing.
Main Methods:
- A full-thickness excisional wound model in rats was used.
- WDE, sham device, and Constant Current (CC) stimulator were applied daily for 13 days.
- Histological and immunofluorescence analyses were performed on day 14.
- A cellular-resolution dosimetry model (BEM-FMM) was developed.
Main Results:
- WDE reduced time to 50% wound closure by ~29% compared to sham.
- Enhanced tissue remodeling observed: increased collagen (~25%), cellularity (~73%), αSMA (~2.6-fold), CD31 (~2.0-fold).
- Modulation of M1 and M2 macrophage markers (iNOS ~1.7-fold, CD206 ~2.0-fold) was noted.
Conclusions:
- WDE is a practical bioelectric wound dressing that accelerates wound healing.
- The device simplifies electrical stimulation application, integrating with standard wound care.
- Findings establish WDE's potential for clinical translation in wound management.
