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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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Potential new targets for rheumatic diseases
1Rheumatologisches Versorgungszentrum (RVZ), Ruhr Universität Bochum und RVZ Steglitz, Berlin, Germany.
EULAR Rheumatology Open
|August 1, 2026
Summary
New targets and agents offer novel treatment options for autoimmune diseases like rheumatoid arthritis. This review discusses emerging therapies beyond conventional, biologic, and targeted synthetic disease-modifying antirheumatic drugs.
Area of Science:
- Rheumatology and Immunology
- Pharmacology
Background:
- Autoimmune diseases, including rheumatoid arthritis and connective tissue diseases, have numerous established and emerging therapeutic targets.
- Conventional (c), biologic (b), and targeted synthetic (ts) disease-modifying antirheumatic drugs are standard in rheumatologic care.
- Specialists across oncology, gastroenterology, and dermatology also utilize immunomodulatory agents.
Purpose of the Study:
- To present and discuss novel therapeutic targets and agents for rheumatic musculoskeletal diseases.
- To provide an overview of recent advancements in the treatment landscape of autoimmune conditions.
Main Methods:
- This is a narrative review.
- Literature search on new targets and agents for autoimmune and rheumatic diseases.
Main Results:
- Several new targets and agents show potential for treating rheumatic musculoskeletal diseases.
- The review highlights advancements beyond current standard therapies.
Conclusions:
- Emerging therapeutic strategies offer promising new avenues for managing autoimmune and rheumatic diseases.
- Continued research into novel targets and agents is crucial for improving patient outcomes.
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