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Updated: Aug 5, 2026
10:28
The Encapsulation of Cell-free Transcription and Translation Machinery in Vesicles for the Construction of Cellular Mimics
Published on: October 21, 2013
Stimuli-Responsive Cell-Mimetic Vesicles for Advanced Pharmaceutical Systems
Hyewon Jeon1, Jaehyun Cheong1, Jain Koo1
1Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, Seoul, Republic of Korea.
International Journal of Nanomedicine
|August 1, 2026
Summary
Vesicles are evolving from simple drug carriers into smart, cell-like therapeutic systems. This review explores their progression towards programmable nanomedicines with enhanced targeting and controlled release capabilities.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Vesicles offer versatile drug delivery, co-encapsulating diverse cargos for combination therapies.
- Stimuli-responsive functionalities enhance targeting, control drug release, and reduce toxicity.
- Vesicle systems are advancing into artificial cells with biosynthesis and communication capabilities.
Purpose of the Study:
- To provide a comprehensive perspective on the functional evolution of vesicle-based systems.
- To integrate advances in drug delivery, stimuli-responsive vesicles, and artificial cells.
- To examine the progression of vesicles from carriers to adaptive, cell-mimetic therapeutic platforms.
Main Methods:
- Review and integration of recent advances in vesicle engineering.
- Emphasis on structural design principles for functional diversification.
- Analysis of targeting moieties, stimuli-responsive elements, and artificial cell features.
Main Results:
- Vesicular platforms are transforming into programmable therapeutic entities.
- Structural designs enable enhanced targeting, controlled release, and biomolecule production.
- Artificial cell-like systems demonstrate in situ biosynthesis and intercellular communication.
Conclusions:
- Vesicle engineering has progressed from passive nanocarriers to sophisticated, adaptive systems.
- Rational design of next-generation nanomedicines requires addressing challenges in stability, responsiveness, and integration.
- Future nanomedicines will leverage vesicle platforms for multifunctional and programmable therapeutic applications.
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