Related Experiment Video
Updated: Aug 5, 2026
09:04
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
T cell-based immunotherapy in solid tumors: mechanistic barriers and emerging opportunities
Hojin Chun, Hyunjin Ju, Sung-Min Hwang1
1Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
BMB Reports
|August 3, 2026
Summary
T cell immunotherapies show promise for solid tumors but face barriers like tumor microenvironments and T cell exhaustion. Overcoming these requires reprogramming T cells and adapting them to the tumor context for durable immunity.
Area of Science:
- Immunology
- Oncology
- Cancer Therapy
Background:
- T cell-based immunotherapies have revolutionized hematological cancer treatment.
- Their effectiveness in solid tumors is limited by numerous intrinsic and microenvironmental barriers.
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