Related Experiment Video
Updated: Aug 5, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Does permanent tooth eruption introduce periodontal pathogens? A preliminary study
Shao Bing Fong1, Emile Boyer1, Alexia Marie-Cousin1
1INSERM, University of Rennes, CHU Rennes, INRAE, UMR 1317, Nutrition Metabolisms and Cancer (NuMeCan) Institute, Rennes, France.
Odontology
|August 3, 2026
Summary
Permanent teeth eruption may introduce disease-associated bacteria into the oral microbiota. Deeper sulcus formation during this stage creates a niche for early colonization by periodontal pathogens, potentially leading to future gum disease.
Area of Science:
- Microbiology
- Periodontology
- Dental Health
Background:
- The eruption of permanent teeth can influence the colonization of the periodontal sulcus by pathogenic oral bacteria.
- Understanding the oral microbiota's evolution during tooth eruption is crucial for assessing periodontal disease risk.
Purpose of the Study:
- To analyze the changes in the oral microbiota composition during the eruption of permanent teeth.
- To identify specific bacterial species associated with the transition from primary to permanent teeth eruption.
Main Methods:
- Sub-gingival microbiome analysis using 16S rRNA sequencing.
- Comparison of microbial samples from primary teeth sulci, erupting permanent teeth sulci (case-matched), and periodontitis controls.
Main Results:
- Disease-associated bacteria, including Tannerella forsythia, Treponema denticola, and Fretibacterium sp. HMT 360, were detected in erupting permanent teeth samples.
- These specific pathogens were absent in the samples from primary teeth.
- The formation of a deeper sulcus during permanent teeth eruption appears to facilitate early colonization by periodontal pathogens.
Conclusions:
- Permanent teeth eruption creates an environment conducive to the colonization of periodontal pathogens in children and young adults.
- This early colonization may represent a risk factor for the development of periodontal diseases later in life.
- Monitoring the oral microbiota during tooth transition is important for early detection and prevention strategies.
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