Related Experiment Video

Updated: Aug 5, 2026

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
08:26

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

A multifunctional Janus-inspired therapeutic patch enabling intraoperative control of tumor dissemination and

Xuan Pan1, Xiaoming Wang1, Qin Dang2

  • 1Department of Hepato-Biliary-Pancreatic Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, 241000, China.

Materials Today. Bio
|August 4, 2026
PubMed

Insights

A novel Janus-inspired therapeutic patch (JTP) effectively controls pancreatic cancer recurrence by managing bleeding, capturing tumor cells, and delivering chemotherapy directly to the surgical site, improving survival rates.

Area of Science:

  • Biomaterials Science
  • Surgical Oncology
  • Drug Delivery Systems

Background:

  • Postoperative recurrence and metastasis are major challenges in pancreatic ductal adenocarcinoma (PDAC) following surgical resection.
  • Current surgical techniques lack effective intraoperative strategies to prevent tumor dissemination and residual disease.

Purpose of the Study:

  • To develop and evaluate a multifunctional Janus-inspired therapeutic patch (JTP) for intraoperative control of PDAC recurrence.
  • To integrate hemostasis, tumor cell capture, and localized chemotherapy into a single implantable device.

Main Methods:

  • A trilayer JTP was designed with a gelatin-hyaluronic acid sponge for hemostasis and tumor cell capture, a gemcitabine-loaded polylactic acid nanofiber layer for sustained drug release, and a polycaprolactone backing for barrier function.
  • The JTP's performance was assessed in an orthotopic PDAC resection model, evaluating hemostasis, tumor suppression, metastasis inhibition, and survival rates.

Main Results:

  • The JTP demonstrated rapid hemostasis within 1.24 minutes and significantly reduced blood loss by 78%.
  • The patch achieved approximately 89% tumor suppression and substantially inhibited hepatic metastasis.
  • JTP implantation extended survival to 38 days with an 80% survival rate in the PDAC model.

Conclusions:

  • The Janus-inspired therapeutic patch offers a promising strategy to bridge surgical resection and localized chemotherapy for improved postoperative PDAC management.
  • This multifunctional patch transforms the surgical site into an active therapeutic interface, effectively controlling tumor recurrence and metastasis.
Keywords:
CTC captureImplantable membranePDAC therapyPostoperative recurrenceUnidirectional drug release

More Related Videos

Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch07:05

Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch

Published on: February 10, 2015

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...