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Metal-enhanced fluorescent sensor system for bisphenol a determination using AgNP-modified molecularly imprinted
Daria Yarynka1, Roman Nikolaiev1, Oleksandr Brovko2
1Institute of Molecular Biology and Genetics of the NAS of Ukraine Zabolotnogo Str. 150 Kyiv 03143 Ukraine d.v.yarynka@nas.gov.ua.
RSC Advances
|August 4, 2026
Summary
A novel metal-enhanced fluorescence sensor detects bisphenol A (BPA) using silver nanoparticles and imprinted polymer films. This sensitive system offers accurate BPA detection in wastewater, aiding environmental monitoring.
Area of Science:
- Analytical Chemistry
- Materials Science
- Environmental Science
Background:
- Bisphenol A (BPA) is an endocrine-disrupting chemical with significant environmental and health concerns.
- Accurate and sensitive detection methods for BPA are crucial for environmental monitoring and public health protection.
- Existing detection methods may lack the required sensitivity, selectivity, or robustness for real-world samples.
Purpose of the Study:
- To develop a novel metal-enhanced fluorescence (MEF) sensor system for the sensitive and selective detection of bisphenol A (BPA).
- To integrate molecularly imprinted polymer (MIP) films with in situ synthesized silver nanoparticles (AgNPs) for enhanced fluorescence.
- To evaluate the analytical performance and applicability of the developed sensor for BPA detection in environmental samples.
Main Methods:
- Fabrication of MIP films containing ethylene glycol methacrylate phosphate (EGMP) with in situ synthesized silver nanoparticles (AgNPs).
- Utilizing the metal-enhanced fluorescence (MEF) phenomenon for signal amplification.
- Characterization of sensor performance, including detection limit, linear dynamic range, and selectivity against structural analogues.
- Application of the sensor for BPA detection in spiked wastewater samples.
Main Results:
- The MEF sensor achieved a low detection limit of 0.1 nM for BPA.
- A wide linear dynamic range of 0.1 nM–25 µM was established for BPA detection.
- The AgNP-MIP films demonstrated significantly higher selectivity for BPA over structurally related compounds.
- Successful detection of BPA in spiked wastewater samples, validating the sensor's practical applicability.
Conclusions:
- The developed MEF sensor system offers a highly sensitive and selective method for BPA detection.
- The combination of MIP films and AgNPs via MEF provides a powerful platform for enhanced fluorescence sensing.
- The sensor shows great potential for robust and sensitive environmental monitoring of BPA in complex matrices like wastewater.
