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Managing Erythromelalgia-Associated Pain with Suzetrigine: A Case Report
Don Hoang1, Jennifer Hubbell1, Thomas Verbeek1
1Department of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, PA.
Pain Medicine Case Reports
|August 4, 2026
Summary
Suzetrigine, a selective Nav1.8 inhibitor, provided significant pain relief for a patient with erythromelalgia. This novel treatment shows promise for managing this debilitating chronic pain condition.
Area of Science:
- Neurology
- Pharmacology
- Pain Management
Background:
- Erythromelalgia is a rare, chronic condition causing burning pain, erythema, and warmth, primarily in the feet.
- Current management of erythromelalgia is challenging, with nonselective sodium channel blockers offering limited utility.
- Selective Nav1.8 sodium channel inhibitors like suzetrigine present potential antinociceptive benefits.
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