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Updated: Aug 11, 2026
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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Outcomes with Endogenous Endophthalmitis from Candidal versus Bacterial Sepsis
Neil S Dogra1, John B Bond2, Mark P Breazzano3
1University of Rochester School of Medicine and Dentistry, Rochester, NY.
Ophthalmology. Retina
|August 4, 2026
Summary
Candida endophthalmitis patients had lower rates of retinal detachment and vitreoretinal intervention compared to bacterial sepsis patients. However, candidal sepsis was linked to higher all-cause mortality, suggesting a potentially lower ophthalmic risk despite greater systemic morbidity.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Critical Care Medicine
Background:
- Endogenous endophthalmitis is a severe intraocular infection.
- Distinguishing ophthalmic outcomes between fungal (Candida) and bacterial sepsis is crucial for patient management.
- Large-scale data analysis is needed to compare these outcomes.
Purpose of the Study:
- To compare one-year ophthalmic outcomes in endogenous endophthalmitis following candidal versus bacterial sepsis.
- Utilize a large, multicenter electronic health record database for robust comparison.
Main Methods:
- Retrospective, propensity score-matched cohort study.
- Utilized the TriNetX Analytics Network database.
- Matched patients 1:1 based on various demographic and clinical factors.
Main Results:
- Candidal sepsis showed significantly lower rates of retinal detachment (3.8% vs. 7.8%) and vitreoretinal intervention (4.1% vs. 14.2%) compared to bacterial sepsis.
- Composite vision/globe loss was significantly lower in the candidal group (4.3% vs. 26.6%).
- One-year mortality was higher in the candidal sepsis group (35.4% vs. 25.3%).
Conclusions:
- Candida endophthalmitis is associated with lower ophthalmic complication rates (retinal detachment, vitreoretinal intervention) than bacterial sepsis.
- Despite lower ophthalmic risk, candidal sepsis carries a higher risk of all-cause mortality.
- Further prospective studies are warranted to confirm these pathogen-specific ophthalmic risks.
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