RETINAL DETACHMENT AFTER ENDOGENOUS ENDOPHTHALMITIS: A Multicenter Study

Area of Science:

• Ophthalmology
• Infectious Diseases
• Retinal Surgery

Background:

• Endogenous endophthalmitis (EE) is a serious intraocular infection.
• Retinal detachment (RD) is a potential complication of EE.
• Identifying risk factors for RD in EE is crucial for timely intervention.

Purpose of the Study:

• To determine factors associated with the development of retinal detachment (RD) in eyes diagnosed with endogenous endophthalmitis (EE).

Main Methods:

• A multicenter retrospective study included 201 eyes from 171 patients with EE across seven tertiary care centers.
• Data collected included demographics, medical history, ocular findings, and microbial cultures.
• Subsequent RD within six months of EE diagnosis was assessed relative to presenting factors.

Main Results:

• Retinal detachment (RD) occurred in 22.4% of eyes with endogenous endophthalmitis (EE).
• Eyes that developed RD had significantly worse presenting visual acuity (VA) and lower intraocular pressure (IOP).
• Staphylococcus aureus bacteremia was strongly associated with an increased risk of subsequent RD (OR: 6.10).

Conclusions:

• Eyes presenting with visual acuity of light perception (LP) or Staphylococcus aureus bacteremia are at higher risk for RD following EE.
• These high-risk eyes may benefit from closer surveillance.
• Therapeutic pars plana vitrectomy (PPV) was not associated with an increased risk of RD and may be beneficial in select cases.