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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Related Experiment Video

Updated: Jul 2, 2026

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
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RETINAL DETACHMENT AFTER ENDOGENOUS ENDOPHTHALMITIS: A Multicenter Study.

Peter J Weng1, Richmond Woodward1,2, Walter Duy3

  • 1Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina.

Retina (Philadelphia, Pa.)
|February 18, 2026
PubMed
Summary
This summary is machine-generated.

Eyes with poor vision or Staphylococcus aureus bacteremia face higher retinal detachment risk after endogenous endophthalmitis. Closer monitoring is advised for these patients.

Keywords:
bacteremiaendogenous endophthalmitispars plana vitrectomyretinal detachment

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Retinal Surgery

Background:

  • Endogenous endophthalmitis (EE) is a serious intraocular infection.
  • Retinal detachment (RD) is a potential complication of EE.
  • Identifying risk factors for RD in EE is crucial for timely intervention.

Purpose of the Study:

  • To determine factors associated with the development of retinal detachment (RD) in eyes diagnosed with endogenous endophthalmitis (EE).

Main Methods:

  • A multicenter retrospective study included 201 eyes from 171 patients with EE across seven tertiary care centers.
  • Data collected included demographics, medical history, ocular findings, and microbial cultures.
  • Subsequent RD within six months of EE diagnosis was assessed relative to presenting factors.

Main Results:

  • Retinal detachment (RD) occurred in 22.4% of eyes with endogenous endophthalmitis (EE).
  • Eyes that developed RD had significantly worse presenting visual acuity (VA) and lower intraocular pressure (IOP).
  • Staphylococcus aureus bacteremia was strongly associated with an increased risk of subsequent RD (OR: 6.10).

Conclusions:

  • Eyes presenting with visual acuity of light perception (LP) or Staphylococcus aureus bacteremia are at higher risk for RD following EE.
  • These high-risk eyes may benefit from closer surveillance.
  • Therapeutic pars plana vitrectomy (PPV) was not associated with an increased risk of RD and may be beneficial in select cases.