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Long term outcomes after ICU
Nathalie Van Aerde1, Greet Hermans2
1Department of Intensive Care Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussel, Belgium.
Best Practice & Research. Clinical Anaesthesiology
|August 4, 2026
Summary
Post-intensive care syndrome (PICS) affects over half of ICU survivors, causing long-term physical, cognitive, and mental health issues. Early intervention and the ABCDEF bundle can mitigate PICS and improve patient outcomes.
Area of Science:
- Critical Care Medicine
- Patient Outcomes
- Long-term Health
Background:
- Post-intensive care syndrome (PICS) is a prevalent condition affecting over 50% of ICU survivors.
- PICS encompasses persistent physical, cognitive, and mental health impairments, significantly impacting quality of life and functional recovery.
- The effects of PICS extend to family members (PICS-F), causing psychological distress and reduced well-being.
Purpose of the Study:
- To summarize the multifaceted nature of PICS.
- To identify risk factors and outline preventive strategies for PICS.
- To emphasize the importance of early screening and structured follow-up for PICS management.
Main Methods:
- Review of existing literature on Post-Intensive Care Syndrome.
- Analysis of PICS prevalence, symptoms, and impact on survivors and families.
- Evaluation of the ABCDEF bundle as a preventive strategy.
Main Results:
- PICS involves significant physical limitations (ICU-acquired weakness, reduced exercise capacity), cognitive impairment, and mental health disorders.
- Premorbid vulnerability and ICU exposures are key risk factors for PICS.
- The ABCDEF bundle is a key strategy for optimizing ICU care and preventing PICS.
Conclusions:
- PICS is a complex syndrome with lasting effects on survivors and their families.
- Optimizing ICU care through strategies like the ABCDEF bundle is crucial for PICS prevention.
- Structured follow-up and early screening are recommended for high-risk patients to guide PICS management.
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