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Updated: Aug 11, 2026

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
Published on: April 6, 2015
Interleukin-25: orchestrating resistance to intestinal helminth infections
Paola Cociancic1, Emma Fiallos1, José Guillermo Esteban1
1Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Área de Parasitología, Facultad de Farmacia y Ciencias de la Alimentación, Universitat de València, Valencia, Spain.
None:
Interleukin-25 (IL-25) has emerged as a central regulator of type 2 immunity at mucosal surfaces. Beyond its classical role as an epithelial alarmin, IL-25 acts as a multifunctional coordinator of epithelial sensing, immune activation, and tissue adaptation during helminth infection. In the intestine, tuft cells detect helminth- and microbiota-derived metabolites and activate a feed-forward circuit with type 2 innate lymphoid cells (ILC2s), promoting antiparasitic immunity and barrier protection. Emerging evidence further links IL-25 to neuroimmune communication, epithelial remodeling, tissue resilience, and disease tolerance. Here, we summarize recent advances in IL-25 biology, including ILC2 specialization and the distinct roles of IL-25 in nematode and trematode infections, highlighting its potential as a therapeutic target to enhance mucosal protection while limiting immunopathology.
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