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Updated: Aug 6, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
Published on: May 14, 2021
Ubiquitin family as novel protein partners for molecular glues
1Department of Synthetic Molecular Design, Biogen Inc., Cambridge, MA, USA. laura.silvian@biogen.com.
Abstract:
Molecular glues are small molecules that induce ternary complexes between a protein of interest and a partner protein, creating therapeutic mechanisms distinct from traditional inhibitors. This minireview examines binding-site architectures of clinically tested molecular glues and extends these insights to ubiquitin-family partner proteins. Structural analysis suggests recurring recognition features, while emerging computational methods may accelerate discovery and optimization of ubiquitin-directed glues for therapeutic applications.
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