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Updated: Aug 7, 2026
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Head and Neck Verrucous Carcinoma: A European Multicenter Retrospective Study
Anne-Sophie Schrooyen1, Luigi Angelo Vaira2,3, Paolo Boscolo-Rizzo2,4
1Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, Brussels, Belgium.
Background:
We characterized oncological outcomes of head and neck verrucous carcinomas (HNVC) and explored treatment-associated outcomes.
Methods:
Medical records of 106 HNVC patients (1994-2024) were reviewed, analyzing clinical history, tumor characteristics, treatment modality, and outcomes.
Results:
Among 106 patients, 101 underwent surgery. Five-year overall survival and recurrence-free survival were 82.2% and 85.3%, respectively. Cox regression identified age ≥ 65 years as significantly increasing recurrence risk (HR = 5.989; 95% CI 2.02-17.77), while tobacco consumption decreased risk (HR = 0.309; 95% CI 0.12-0.81). Clinical T stage influenced recurrence: cT2 (HR = 0.22), cT3 (HR = 1.366), cT4 (HR = 1.525). Compared with local resection, partial organ resection (HR = 0.841) and total organ resection (HR = 0.501) showed lower recurrence rates.
Conclusion:
HNVC demonstrates excellent five-year survival. Surgery remains the primary treatment, with wider resections significantly reducing recurrence risk, emphasizing the importance of achieving clear margins for durable local control.
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