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Efficient Antimicrobial Nanoenzymatic Functionalized Hydrogels for Diabetic Infected Wound Treatment
Changyu Yao1, Dongqin Zhang1, Jiaqi Kan1
1School of Life Sciences and Medical Engineering, Anhui University, 111 Jiulong Road, Hefei, Anhui230601, China.
ACS Biomaterials Science & Engineering
|August 6, 2026
Summary
Diabetic wound infections are inhibited by a novel nanoenzyme-functionalized hydrogel (ZAG@Gel). This advanced wound dressing promotes healing by reducing bacterial load and regulating the wound microenvironment, achieving a 98.06% healing rate in animal models.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Diabetic wounds are prone to bacterial infections due to high glucose levels, hindering the healing process.
- Effective treatment requires inhibiting infection and optimizing the wound microenvironment.
Purpose of the Study:
- To develop a nanoenzyme-functionalized hydrogel for treating diabetic infected wounds.
- To investigate the antibacterial activity and wound healing efficacy of the developed hydrogel.
Main Methods:
- Gold nanoparticles (Au NPs) and glucose oxidase (GOx) were loaded onto zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) to create ZIF-8@Au@GOx (ZAG) nanoenzymes.
- ZAG nanoenzymes were incorporated into a dynamic adaptive (DSA) hydrogel, forming ZAG@Gel.
- In vitro and in vivo studies assessed antibacterial activity and wound healing rates.
Main Results:
- ZAG nanoenzymes effectively reduced glucose levels, lowered pH, and produced hydroxyl radicals, exhibiting potent antimicrobial activity.
- ZAG@Gel demonstrated significant bacterial membrane disruption in vitro.
- In vivo experiments showed ZAG@Gel achieved a wound healing rate of nearly 98.06%.
Conclusions:
- The ZAG@Gel hydrogel is a highly effective antibacterial agent for diabetic infected wounds.
- This nanoenzyme-functionalized hydrogel shows promising pro-healing properties by modulating the wound microenvironment and eliminating bacteria.
