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Updated: Aug 8, 2026
08:56
Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
The Rosa roxburghii genome provides insights into triterpenoid metabolism
Huayue Zhang1, Yuezhu Wang1, Ming-Jie Li1
1Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China.
Plant Physiology and Biochemistry : PPB
|August 6, 2026
Summary
This study reveals that Rosa roxburghii
Area of Science:
- Genomics and Plant Biochemistry
- Focuses on the biosynthesis of bioactive compounds in horticultural crops.
Background:
- Rosa roxburghii fruits are rich in nutritional and medicinal triterpenoids.
- Understanding triterpenoid biosynthesis is key to improving this functional fruit crop.
Purpose of the Study:
- To provide a multi-omics insight into triterpenoid biosynthesis in Rosa roxburghii.
- To identify key genes and evolutionary patterns in triterpenoid metabolic pathways.
Main Methods:
- Generated a chromosome-scale genome assembly for Rosa roxburghii.
- Performed genome-wide identification of squalene epoxidase (SQLE) and oxidosqualene cyclase (OSC) genes.
- Integrated transcriptomic and metabolomic profiling across fruit development.
Main Results:
- Identified 22 SQLE and 14 OSC genes, with SQLEs expanding via tandem duplications and OSCs undergoing gene loss.
- Upregulation of specific RroSQLEs correlated with increased total triterpenoids.
- Downregulation of specific RroOSCs was linked to altered triterpenoid composition, reducing saponins.
Conclusions:
- Suggests a decoupled evolutionary strategy between precursor supply and diversification in triterpenoid biosynthesis.
- Provides a valuable genomic resource and candidate genes for R. roxburghii metabolic engineering.
- Highlights potential for quality improvement of this medicinal fruit crop.
Keywords:
Fruit developmentGene family evolutionMulti-omics integrationOxidosqualene cyclaseRosa roxburghiiSqualene epoxidaseTriterpenoid metabolismMore Related Videos
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