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Updated: Aug 8, 2026
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Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
Vitreoretinal lymphoma revealing Richter transformation
Dibya Prabha1, Vishal Raval1,2, Dilip Mishra3
1Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India.
American Journal of Ophthalmology Case Reports
|August 7, 2026
Summary
This case report details a rare instance of Richter syndrome transformation, manifesting as diffuse large B-cell lymphoma in the eye, in a patient with chronic lymphocytic leukemia. Early diagnosis and intervention are crucial for managing this rare ocular complication.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy.
- Richter syndrome is a transformation of CLL into aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL).
- Ocular involvement in Richter syndrome is rare, with vitreoretinal lymphoma being an uncommon presentation.
