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Published on: May 20, 2019
Single particle - MC-ICP-MS for isotopic analysis of uranium particles
Benjamin T Manard1, Daniel R Dunlap1, Sarah E Szakas1
1Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37830, USA. manardbt@ornl.gov.
Analytical Methods : Advancing Methods and Applications
|August 7, 2026
Summary
Single particle multi-collector inductively coupled plasma mass spectrometry (SP-MC-ICP-MS) precisely measured uranium isotopes in micron-sized particles. This method optimizes detector configurations for accurate isotopic analysis, crucial for nuclear forensics and geochemistry.
Area of Science:
- Analytical Chemistry
- Nuclear Chemistry
- Geochemistry
Background:
- Accurate isotopic composition of uranium particles is vital for nuclear forensics, safeguards, and geochemical studies.
- Traditional methods struggle with precise analysis of trace elements in individual micron-sized particles.
Purpose of the Study:
- To optimize single particle multi-collector inductively coupled plasma mass spectrometry (SP-MC-ICP-MS) for precise uranium isotope ratio measurements.
- To evaluate the impact of different detector combinations and integration times on accuracy and precision.
- To determine the isotopic composition of individual U3O8 particles.
Main Methods:
- Utilized SP-MC-ICP-MS to analyze 1 µm U3O8 particles.
- Investigated various detector combinations (SEM, Faraday) and integration times (5-50 ms).
- Focused on 234U/238U, 235U/238U, and 236U/238U isotopic ratios.
Main Results:
- Dual Faraday detector with 10^11 Ω amplifier optimized 235U/238U measurements, achieving -1.8% relative difference.
- Determined minor isotopic ratios: 234U/238U (0.0000070 ± 0.0000014) and 236U/238U (0.0000758 ± 0.0000048).
- Achieved measurement sensitivity down to atto-grams (ag) of 234U and 236U, with a limit of detection around 1.0 ag.
Conclusions:
- SP-MC-ICP-MS is a powerful technique for high-precision uranium isotope analysis in individual micron-sized particles.
- Optimized detector configurations and integration times enhance accuracy and precision.
- This method has significant applications in nuclear forensics, safeguards, and geochemical analysis.

