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Invasive Breast Cancer Complicated by Colitis After TCbHP Chemotherapy: A Case Report
Zicong You1, Yue Deng2, Shiying Cao1
1Department of Thoracic and Breast Surgery, The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, China.
Chemotherapy for breast cancer can rarely cause colitis, a serious side effect. Modifying the treatment regimen, as shown in this case, can help manage symptoms and prevent severe complications.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Breast cancer treatment commonly involves chemotherapy, with known side effects like nausea and myelosuppression.
- Chemotherapy-induced colitis is a rare but serious adverse event with unclear mechanisms.
Purpose of the Study:
- To increase awareness of chemotherapy-induced colitis in breast cancer patients.
- To present a case study and discuss practical approaches to modifying chemotherapy regimens.
Main Methods:
- A case report of a 53-year-old woman with Stage IIA invasive breast carcinoma treated with TCbHP chemotherapy.
- Monitoring of symptoms, colonoscopies, and regimen adjustments (dose reduction, then regimen change to THP).
Main Results:
- The patient developed colitis after the first cycle of TCbHP chemotherapy.
- Dose reduction led to recurrence of symptoms and colonic ulcers.
- Switching to the THP regimen resulted in symptom resolution and ulcer healing.
Conclusions:
- Chemotherapy-induced colitis is a rare complication of breast cancer treatment, posing diagnostic and therapeutic challenges.
- Prompt intervention and regimen modification may prevent severe complications like intestinal necrosis.
- Further research is needed due to the single-case nature and combination chemotherapy used.
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