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Updated: Aug 11, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
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Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

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Cocaine-Induced Midline Destructive Lesions: A Historical Review of Diagnostic Mimicry

Anna Onderková1, Marlene M Speth2, Hesham A Saleh3

  • 1Department of Otorhinolaryngology & Head and Neck Surgery, University Hospital Královské Vinohrady, Prague, Czech Republic.

The Laryngoscope
|August 10, 2026
PubMed

Keywords:
ANCACIMDLcocainegranulomatosis with polyangiitishistorical reviewlevamisolemidline destructive lesionnasal septum perforation

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Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

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Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...