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Retrospective Analysis of Acute Toxicity Following Breast Cancer Re-Irradiation
Alyssa Jiaxin Wang1, Shely Kagan2, Liying Zhang3
1Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Clinical Breast Cancer
|August 10, 2026
Summary
Breast re-irradiation is well-tolerated acutely, with lower skin toxicity than initial treatment. Radiation dose and delivery influenced toxicity patterns, not prior treatment history.
Area of Science:
- Oncology
- Radiation Oncology
- Clinical Cancer Research
Background:
- Breast cancer recurrence often necessitates re-irradiation.
- Assessing acute toxicity is crucial for patient management.
- Understanding factors influencing toxicity guides treatment planning.
Purpose of the Study:
- Evaluate acute skin toxicity in breast re-irradiation.
- Identify treatment-related factors affecting toxicity.
- Compare toxicity between initial and repeat radiation courses.
Main Methods:
- Retrospective review of 70 patients with breast cancer recurrence.
- Analysis of patient characteristics and treatment parameters.
- Clinician-graded acute toxicity assessment.
Main Results:
- Lower acute skin toxicity during re-irradiation (22.9%) vs. initial treatment (51.4%).
- Severe toxicity, including moist desquamation, was uncommon (14.3%).
- No significant association between prior toxicity and re-irradiation toxicity (P=.75).
Conclusions:
- Breast re-irradiation is generally well-tolerated acutely.
- Radiation dose and delivery are key toxicity determinants.
- Further prospective studies are needed for long-term outcome assessment.
Keywords:
Acute skin toxicityChest wall irradiationIpsilateral breast tumor recurrenceRadiation dermatitisRadiotherapy retreatment
